ABC’s  comedy “Up All Night” was on the bubble and in the midst of a revamp… but that bubble may have burst. Star Christina Applegate announced Friday she is leaving the series. According to the Associated Press,  the actress decided to leave after the show headed in a “different creative direction.”

A more certain fate awaits neurosurgeon-with-an-alter-ego drama “Do No Harm.” After only two episodes, NBC has canceled the show.